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There is something I have always found remarkable: consider the following construction.
Let be a category, and the functor sending into the slice category . More formally, this can be regarded as the functor sending to the category of elements of the representable presheaf on .
Now, building the category of elements of one gets the category of arrows over , and the associated fibration is just the codomain fibration.
Very good! Now let's tweak this construction a little bit, and let's postcompose with the opping endofunctor of , sending to the opposite of the slice over C, i.e. . What we get is if we take the Grothendieck construction now is... the twisted arrow category of ! Something so different, changing so little.
The most intuitive explanation I can give to myself about what's going on is that the morphisms in the total category of the Grothendieck construction of a prestack , and the morphisms in each fiber subcategory are of different kinds. Opping the latter does not result in some meaningful opping on the morphisms of the former.
As elementary and neat as this explanation is, I can't call it satsifying: I'd like to state a more general relation between the Grothendieck construction of a Grothendieck construction "performed fiberwise", and the Grothendieck construction "done just once".
What I have in mind is a theorem on the following lines:
Theorem Let be a profunctor; let be the functor sending to the category of elements of the presheaf . Consider the category , obtained taking the Grothendieck construction of : each fiber of this category over C will be . On the other hand, consider the category of elements of , done all at once. This is also called the "collage" of along . Then, and stand in the following relation: [...fill in the dots...]
In case what we get is that is the arrow category, and is the twisted arrow category.