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Let and be functors. I know that exists when is small, but are there any weaker sufficient conditions for its existence?
If F has an adjoint G (left or right? off the top of my head i can't quite remember) then the left Kan extension of I along F is given by GI.
The "pointwise" Kan extension, by definition, requires certain colimits to exist and these are the most important ones from both a theoretical and practical pov (theoretically they have certain richer properties than an arbitrary Kan extension) so you definitely want these colimits to exist, either you need C to be small or you need a way of reducing large limits to small limits by imposing some kind of well-behavedness on the category, a kind of solution set condition like in the case of the adjoint functor theorem or perhaps a "filtering" condition like when we assume that a class of morphisms in a category admits a calculus of fractions (this amounts to saying certain kinds of diagrams that we want to take colimits of are filtered)
The Kan extensions arising from adjoints are also pointwise, and even absolute.
Instead of requiring to be small, it is enough to require each to be a small functor (the left Kan extension of its restriction to some small full subcategory , see https://web.science.mq.edu.au/~slack/papers/small.pdf). This suffices for existence of pointwise left Kan extensions along , because
which is a small colimit.
This includes the case where has a right adjoint , because , which is the left Kan extension of its restriction to .
Follow-up question: Is it true that whenever a set-valued Kan extension exists it is then pointwise?
It's hard to come up with examples of non-pointwise Kan extensions, but I certainly don't see any reason why that would be true.
Because is nice I guess...I don't have a clear intuition