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More precisely: is it possible to consider "algebras" for an endo-profunctor as inserters of and hom?
(I suspect it does not, with some negative thinking in Prof{0,1} = Rel)
Not sure if this helps but there is already a notion of algebra for a profunctor. There was some discussion on this server a while back about it, and I believe if I remember correctly categories of algebras of profunctors corresponded to generic inserters in Cat between any two parallel functors out of C (not just a functor and a hom functor) since they generalized algebras for endofunctors like how profunctors generalize functors. Hope that helps!