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When is a Kan enriched category, then there is a functor of -categories where is the underlying 1-category of . Is it always true that this functor exhibits a localisation of at the homotopy equivalences? If not, are there some tools to check this which are ideally more lightweight than finding a simplicial model category?
It's not always true. For instance, let be a simplicial group with a single 0-simplex; then the corresponding 1-object Kan-enriched category has a terminal underlying 1-category, which it cannot be the localization of.
In the case someone comes across this question in the future, Proposition 1.3.4.7. in Higher Algebra gives a simple way to check if a Kan enriched category is the localisation of its underlying 1-category.